Travel Interstate 40 East to the Old Fort/Route 70 exit. Take Route 70 and follow it until Hwy 221 North in Marion. Take Hwy 221 North until just after Linville, where Hwy 221 North will connect with Hwy 105 North.

Follow Hwy 105 North through the community of Foscoe. After Foscoe, look for Old Shulls Mill Road on the right, just after a billboard for Hound Ears Club. Turn right onto Old Shulls Mill Road and follow until the stop sign, then turn right onto Shulls Mill Road. Drive on Shulls Mill Road for 2.5 miles. Entrance to the Inn at Yonahlossee is on the right.

If you miss the right turn onto Old Shulls Mill Road, or desire a less curvy route, continue on Hwy 105 North toward Boone. About 200 yards after the first stoplight in Boone on the right is Poplar Grove Road, just past the second Tomato Shack on your right (the first one will be on your left before you reach Boone). Follow Poplar Grove Road 3.8 miles until it ends at Shulls Mill Road and turn left. The entrance to the Inn at Yonahlossee is on the right.