Travel Interstate 95 South to Exit 51 for I-85 South, toward Durham and Atlanta. Stay on I-85 South to Exit 123 for I-40 West, toward Greensboro and Winston-Salem, NC. After Winston-Salem, take exit 188 for Hwy 421 North, toward Yadkinville and Wilkesboro; merge onto Hwy 421.

Option 1 (Good Weather):Exit Hwy 421 North to the Blue Ridge Parkway, Southbound. Continue South on the Parkway until just past the Moses Cone Manor House. Exit the Parkway between mile marker 294 and 295 toward Blowing Rock and Hwy 221. Drive 50 feet, then turn right onto Shulls Mill Road. Follow Shulls Mill Road for 2.6 miles. Entrance to the Inn at Yonahlossee is on the left across from the main entrance to the Resort.

Option 2 (Fog or Snowy):Continue on Hwy 421 North into Boone. After New Market Center (Lowes Foods, Hardees, Regal Cinemas) on the right, turn left at the stoplight onto Hwy 105 South; there is a Phillips 66 gas station on the left. Follow Hwy 105 South for 2.8 miles. Just after the Highland Commons Shopping Center (Ingle's Grocery and CVS) on the left, and just before the first Tomato Shack (there is another one further down on right), turn left onto Poplar Grove Road; there is an Amoco gas station on the right for reference. Follow Poplar Grove Road for 3.8 miles until it ends at Shulls Mill Road. Turn left onto Shulls Mill Road. Entrance to the Inn at Yonahlossee is 300 yards ahead on the right.